SAMe - Natural Supplement Everyone Should Know About


SAM-e or S-adenosylmethionine is a naturally made compound that's found in almost every tissue, fluid, some hormones and neurotransmitters in the body. SAMe plays an important role in the body to regulate the immune system, maintains cell membranes, and helps produce and break down brain chemicals, such as serotonin, melatonin, and dopamine. An average adult produces 7-8 g of SAMe each day naturally.

It is produced by the body from Adenosine triphosphate (a major energy source for our body's cells) and the amino acid methionine. SAMe is not found in food. Vitamin B6, B12, and folic acid are required for proper formation and metabolism of SAMe therefore; being deficient in either vitamin B12 and B6 may reduce levels of SAMe in your body.

SAMe is widely available as a supplement and has a number of uses and potential benefits.

Depression
SAMe increases the availaibility of neurotransmitter serotonin and dopamine and is just as effective as antidepressant medications without the side effects. Unlike antidepressants which can take up to 8 weeks, SAMe works in conrolling depression within 2-3 days. Dosage: 800 - 1,600 mg per day, in 2 divided doses 3 months.

Osteoarthritis & Fibromyalgia
SAMe appears to diminish osteoarthritis pain as effectively as non-steroidal anti-inflammatory medication and without any side effects that are associated with NSAIDs such as ibuprofen and naproxen. Researchers have also shown that it may also promote cartilage repair. SAMe may also reduce symptoms of fibromyalgia, a musculoskeletal disorder that causes fatigue, morning stiffness and joint pain. Osteoarthritis Dosage: 600 - 1,200 mg per day in 2 - 3 divided doses. Fibromyalgia Dosage: 400 mg 2 times per day for 6 weeks

Alcoholic Liver Disease
Naturally created SAMe is often not effectively synthesized in people with liver disease and taking SAMe supplement may help treat chronic liver disease caused by medications or alcoholism very effectively. Oral Dosage: 600 - 1,200 mg per day in 2 divided doses for 6 months

Cancer
A study published by National Center for Biotechnology Information suggests SAMe can even effectively inhibit cancer tumor cells especially in gastric and colon cancer.

Side Effects
SAM-e seems to be a relatively safe drug. High doses of oral SAM-e can cause symptoms like gas, upset stomach, diarrhea, constipation, dry mouth, headache, dizziness, anxiety, and skin rashes.

Precautions
- Always consult your health care provider before starting any supplement treatment.
- SAMe is started with a low dose of 200 mg per day and should be increased gradually to avoid stomach upset and abnormally elevated mood. Taking SAMe along with vitamin B12, folic acid, methionine and trimethylglycine will enhance its absorption in the body.
- SAMe should not be given to children, pregnant women and breastfeeding mothers.
- SAMe should never be combined with any other antidepressants.
- People with bipolar disorder (manic depression) should not take SAMe since it may worsen manic episodes.
- Taking SAM along with dextromethorphan (Robitussin), meperidine (Demerol), pentazocine (Talwin), and tramadol (Ultram) may increase the risk of serotonin syndrome, a potentially dangerous condition caused by having too much serotonin.
- Do not take SAMe if you have Parkinson' s disease without talking to your doctor first.